Antidiuretic Effects of Endothelin A Receptor Antagonism
نویسندگان
چکیده
منابع مشابه
Antidiuretic Effects of the Endothelin Receptor Antagonist Avosentan
Several clinical studies have investigated the potential benefits of endothelin receptor antagonism in chronic pathologies such as diabetic kidney disease. However, fluid retention and edema have been identified as major side effects of endothelin receptor antagonists. In the present study we hypothesized that avosentan which was described as a predominant ET(A) receptor antagonist would produc...
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Myocardial depression in sepsis is frequently encountered clinically and contributes to morbidity and mortality. Increased plasma levels of endothelin-1 (ET-1) have been described in septic shock, and previous reports have shown beneficial effects on cardiovascular performance and survival in septic models using ET receptor antagonists. The aim of the current study was to investigate specific c...
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dssue from sham-operated (Sham), untreated-fistula (Fist), and bosentan (100 mg'kg-1'day-r)-treated animals Gist + Bos) was analyzed for mast cell density, MMP activity, and myocardial collagen volume ' : ' H;h;; ai''i and 5 days after the qeation of an aortocaval fistula. r When compared with untreated flstulas, bosentan treafrnent prevented the marked increase in LV mast cell density at I day...
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Background: Recent researches have provided evidences of the importance of endothelin axis in carcinogenesis. According to our knowledge, no data exists about endothelin A receptor (ETA) expression in dysplastic oral mucosa (DOM). Therefore, the aim of the present study was to evaluate immunohistochemical expression of ETA in DOM. Methods:</strong...
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++Endothelin (ET-1) acts as a potent vasoconstrictor in the human kidney, and this vasoconstriction could contribute to the ischemia seen in acute renal failure. In animal studies, the vasoactive properties of ET-1 are known to be ET(A) receptor-and/or ET(B) receptor-mediated; however, the receptor subtype involved in the human kidney remains to be defined. In a phase I, single-center, double-b...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.605.7